2. Signaling Pathways
  3. Immunology/Inflammation
  4. Aryl Hydrocarbon Receptor
  5. Aryl Hydrocarbon Receptor Agonist

Aryl Hydrocarbon Receptor Agonist

Aryl Hydrocarbon Receptor Agonists (42):

Cat. No. Product Name Effect Purity
  • HY-104026
    L-Kynurenine
    		Agonist 99.93%
    L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.
  • HY-15484
    Pifithrin-α hydrobromide
    		Agonist 98.58%
    Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
  • HY-12451
    FICZ
    		Agonist 99.42%
    FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM.
  • HY-W046846
    Corannulene
    		Agonist
    Corannulene is an agonist of aryl hydrocarbon receptor (AhR). Corannulene causes less cytotoxic responses than Benzo[a]pyrene (HY-107377) in hepatoma cells. Corannulene is promising for research of cancers.
  • HY-W517076
    1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin
    		Agonist
    1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin (1,2,3,6,7,8-HxCDD) is an AHR agonist, with reported gene assay EC50 values of 5.4 nM at 4 hours and 9.3 nM at 8 hours. 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin (at doses of 0.5 and 2 µg/kg) has been shown to reduce the production of antibodies against sheep red blood cells in mice. 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin is an environmental pollutant, found in animal feed and detected in the air near municipal waste incinerators.
  • HY-W028393
    Indole-3-pyruvic acid
    		Agonist 99.79%
    Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety.
  • HY-109044
    Tapinarof
    		Agonist 99.95%
    Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice.
  • HY-N0170
    Indole-3-carbinol
    		Agonist 98.87%
    Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).
  • HY-19317
    ITE
    		Agonist 99.27%
    ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity.
  • HY-N0178
    Diosmin
    		Agonist 99.51%
    Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).
  • HY-104026S
    L-Kynurenine-d4
    		Agonist 99.40%
    L-Kynurenine-d4 is the deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist[1][2].
  • HY-114740
    β-Naphthoflavone
    		Agonist 99.95%
    β-Naphthoflavone is an exogenous aryl hydrocarbon receptor (AHR) ligand. β-Naphthoflavone can activate AHR to participate in various biological processes, including cell growth, differentiation, apoptosis, and metabolism. β-Naphthoflavone has antioxidant activity and can exert its antioxidant function by regulating the activity of antioxidant enzymes. β-Naphthoflavone is also a non-carcinogenic CYP1A inducer and can be used to treat aristolochic acid (AAI) induced renal injury.
  • HY-135750
    VAF347
    		Agonist 99.90%
    VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14+CD11b+ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects.
  • HY-W014502
    D-Kynurenine
    		Agonist 99.67%
    D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR).
  • HY-103221
    MeBIO
    		Agonist ≥98.0%
    MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively.
  • HY-W014075
    1-Hydroxypyrene
    		Agonist 99.84%
    1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis.
  • HY-104026R
    L-Kynurenine (Standard)
    		Agonist
    L-Kynurenine (Standard) is the analytical standard of L-Kynurenine. This product is intended for research and analytical applications. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.
  • HY-112627
    CAY 10465
    		Agonist 98.30%
    CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
  • HY-D0932
    Sudan IV
    		Agonist ≥98.0%
    Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.
  • HY-118438
    10-Cl-BBQ
    		Agonist 99.48%
    10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations.